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ea0049gp12 | Adrenal 2 | ECE2017

Activation of the cAMP/PKA transduction system triggers abnormal expression of the serotonin signaling pathway in human adrenocortical cells

Mestre Julie Le , Duparc Celine , Bram Zakariae , Reznik Yves , Bertherat Jerome , Touraine Philippe , Young Jacques , Chabre Olivier , Stratakis Constantine A. , Lefebvre Herve , Louiset Estelle

In human adrenals, serotonin (5-HT), released by subcapsular mast cells, increases aldosterone secretion through activation of type 4 serotonin receptors (5-HT4R) but only exerts a modest control on cortisol production. Interestingly, illicit synthesis of 5-HT in adrenocortical cells as well as overexpression of the 5-HT4R and ectopic expression of the type 7 receptor (5-HT7R) have been observed in bilateral macronodular adrenal hyperplasia res...

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Activation of the cAMP/PKA transduction system triggers abnormal expression of the serotonin signaling pathway in human adrenocortical cells

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